Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 67958179, compound

HRID 72534Notes

Reaction equation

HRID 72534 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:11]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[CH2:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:25][C:26]1([C:29]2[CH:38]=[CH:37][C:32]([C:33]([O:35][CH3:36])=[O:34])=[CH:31][CH:30]=2)[CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:11]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[CH2:12]2)=[C:6]([CH:10]=1)[C:7]([NH:25][C:26]1([C:29]2[CH:38]=[CH:37][C:32]([C:33]([O:35][CH3:36])=[O:34])=[CH:31][CH:30]=2)[CH2:28][CH2:27]1)=[O:9]

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 679585065-Chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinic acid

Product 1

HCID 67958179HCID 67958179, compoundYield 30.6%

Procedure

The title compound (D196) (50 mg) was prepared according to the experimental procedure described in Description 146 starting from 5-chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinic acid (D138) (110 mg, 0.320 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (72.86 mg, 0.320 mmol).

Sources & evidence

ORD record
ord-7b79b4f1271f4c6c8a59460faf859799
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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