HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate → Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)piperidin-1-yl)nicotinamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate | HCID 67958503 | — |
| Reactant | Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate | HCID 86697873 | — |
| Product | Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)piperidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 67958004 | 112% |
Reaction Steps
The title compound (D203) (97 mg) was prepared according to the experimental procedure described in Description 160 starting from tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate (D45) (100 mg, 0.323 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (59 mg, 0.161 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-fd19a8d074d14285b2fe826d89f7c259 |
| Source note | uspto-grants-2014_09 |