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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 72542Erstellt: 25. Oktober 2026

(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate → (S)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72542

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylateHCID 67958745—
EduktMethyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoateHCID 86697873—
Produkt(S)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 86697882111,9%

Reaktionsschritte

The title compound (D204) (101 mg) was prepared according to the experimental procedure described in Description 160 starting from (S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate (D46) (100 mg, 0.355 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D) (D021/056/3) (65 mg, 0.177 mmol).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08828987B2
Quelldatensatzuspto-grants-2014_09
ORD IDord-18cf7095cbb0425bb13a39424d2ad15f
Quellennotizuspto-grants-2014_09