Methyl iodide → HCID 18630005, compound

HRID 725496Notes

Reaction equation

HRID 725496 reaction equation
[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[CH3:19]I>>[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[C:6]([Si:11]([CH3:13])([CH3:12])[CH3:14])=[CH:7][CH:8]=[CH:9][C:10]=1[CH3:19])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630303HCID 18630303, compound

Product 1

HCID 18630005HCID 18630005, compound

Procedure

The compound of Example 50 (1.33 g, 5.0 mmol) and MeI (2.8 g, 20 mmol) were combined according to General Method B. The resulting reaction was partitioned between ethyl acetate and sat aq NaHCO3. The organic phase was washed with brine, dried (MgSO4), and concentrated to afford a quantitative yield of the title compound as an oil.

Workup

  1. customThe resulting reaction
  2. customwas partitioned between ethyl acetate
  3. washThe organic phase was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-9fe0cef3c5774050b971f924b97890ee
Source dataset
uspto-grants-1998_01
Patent number
US05705513

Reaction notes

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