反应详情

To a solution of methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate (D168) (105 mg, 0.206 mmol) in a mixture 1-4 dioxane/water (3 ml/1 ml), 1N NaOH (0.309 ml) was added. The reaction mixture was stirred at room temperature overnight. Organic solvent was evaporated in vacuo and the reaction mixture was acidified with 2N HCl (pH=5-6). The solid obtained was filtered off and dried to afford the title (E34) (65 mg

1. customOrganic solvent was evaporated in vacuo
2. customThe solid obtained
3. filtrationwas filtered off
4. customdried
5. customto afford the title (E34) (65 mg