反应详情

温度

60 °C

To a solution of starting from methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate (D171) (56 mg, 0.107 mmol). in a mixture 1-4 dioxane/water (3 ml/1 ml), 1N NaOH (0.16 ml) was added. The reaction mixture was stirred 2 h at 60° C. Organic solvent was evaporated in vacuo and the reaction mixture was acidified with 2N HCl (pH=2) and the resulting mixture was extracted with ethylacetate (3×5 ml). Combined organics were evaporated in vacuo to afford the title (E37) (53 mg).

1. customOrganic solvent was evaporated in vacuo
2. extractionthe resulting mixture was extracted with ethylacetate (3×5 ml)
3. customCombined organics were evaporated in vacuo
4. customto afford the title (E37) (53 mg)