HCID 53656130, compound → HCID 54418104, compound

Participants

Reaction Steps

1.34 g of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-benzyloxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid (N-butyl)-amide are hydrogenated in the presence of 400 mg of 5% Pd/C in 50 ml of methanol for 10 minutes at room temperature and under normal pressure. The reaction mixture is filtered and concentrated by evaporation. The residue is purified by means of FC (50 g of silica gel, hexane/ethyl acetate=1:1). The title compound is obtained: Rf (hexane/ethyl acetate=1:1)=0.16; HPLC Rt =17.42 minutes; FAB-MS: (M+H)+ =567.

Provenance & Evidence