関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Aminophenol | HCID 5801 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Bromo-2-methylpropionyl bromide | HCID 88685 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide | HCID 14684985 | 921% |
反応手順
To a stirred solution of 2-aminophenol (10 g, 9.2 mmol) in DCM (92 mL) at 0° C. was added 2-bromoisobutyryl bromide (11.4 mL, 9.17 mmol) followed by triethyl amine (12.7 mL, 9.2 mmol) and stirred the reaction mixture at 0° C. for 4 h. Reaction mixture was diluted with DCM 100 mL and then washed with water 100 mL dried over sodium sulfate, concentrated on rotavap to give 2-Bromo-N-(2-hydroxy-phenyl)-2-methyl-propionamide (21.8 g) brown solid which was used for next reaction without purification
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08828951B2 |
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| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-f70754058db14c05b3f9a06965862770 |
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| 出典メモ | uspto-grants-2014_09 |
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