HCID 131719573, compound → HCID 131719572, compound

Participants

Reaction Steps

A solution of 170 mg of 3(S)-isopropyl-5(S)-{1(S)-azido-3(S)-isopropyl-4(R,S)-isobutyryloxy-4-[4-methoxy-3-(2-methoxymethoxyethyl)-phenyl]-butyl}-tetrahydrofuran-2-one in 1.4 ml of butylamine is stirred for 16 hours at room temperature and is then concentrated by evaporation. Purification of the residue by means of FC (hexane/ethyl acetate=7:3) yields the title compound: Rf (hexane/ethyl acetate=7:3)=0.25; HPLC Rt =20.38 and 20.8 minutes (diastereoisomeric mixture).

Provenance & Evidence