HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 725629Generated: October 30, 2026
Hydrochloric Acid → 5(S)-Amino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(3-carbamoyl-propyl)]-amide hydrochloride
https://huagongshe.com/reaction/725629
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(3-carbamoyl-propyl)]-amide | HCID 54299838 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5(S)-Amino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(3-carbamoyl-propyl)]-amide hydrochloride | HCID 23626573 | — |
Reaction Steps
84 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(3-carbamoyl-propyl)]-amide are dissolved in 3 ml of 4N hydrochloric acid in dioxane at 0° C. and the mixture is stirred for 2 hours at 0° C. The reaction mixture is lyophilised. The title compound is obtained: Rf (dichloromethane/methanol=9:1)=0.04; HPLC Rt =9.44 minutes; HR FAB-MS (M+H)+ =510.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05705658 |
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| Source dataset | uspto-grants-1998_01 |
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| ORD ID | ord-2f08f2a4b03a4af794b61991ffc5ed00 |
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| Source note | uspto-grants-1998_01 |
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