反应详情

To a stirred solution of 1-[6-(5-bromo-2-chloro-benzyl)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-2,2,2-trifluoro-ethanone (8.6 g, 19.8 mmol) in ethanol (40 mL) was added NaBH4 portion wise and the reaction mixture was stirred overnight. The excess of NaBH4 was quenched by adding aq. HCl. Ethanol was evaporated and the residue was partitioned between dichloromethane and water. Organic layer was washed with brine, water, dried over sodium sulfate followed by evaporation of solvent furnished 6-(5-bromo-2-chloro-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazine (6.1 g).

1. customThe excess of NaBH4 was quenched
2. additionby adding aq. HCl
3. customEthanol was evaporated
4. customthe residue was partitioned between dichloromethane and water
5. washOrganic layer was washed with brine, water
6. dry with materialdried over sodium sulfate
7. customfollowed by evaporation of solvent