HCID 10975406, compound → HCID 19708593, compound

HRID 725767Notes

Reaction equation

HRID 725767 reaction equation
[Cl:1][C:2]1[C:3](OS(O)(=O)=O)=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:20])[CH2:18][CH3:19])=[C:5]2C.[Cl:27][C:28](=[CH2:31])[CH2:29][NH2:30]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([F:14])([F:13])[F:15])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:20])[CH2:18][CH3:19])=[C:5]2[NH:30][CH2:29][C:28]([Cl:27])=[CH2:31]

Participants

3

Reactant 2

HCID 10975406HCID 10975406, compoundHCID 86751878HCID 86751878, compound

Product 1

HCID 19708593HCID 19708593, compoundYield 71%

Procedure

6- Chloro-4-methylsulfoxy-3-propionyl-8-trifluoromethyl-2-quinolinone (365 mg, 1 mmol) and 2-chloroallylamine (92 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (279 mg, yield: 71%).

Sources & evidence

ORD record
ord-565f7ad8a0994255a3851825128e8012
Source dataset
uspto-grants-1998_01
Patent number
US05707931

Reaction notes

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