(2-(Methylthio)ethyl)amine → HCID 54076699, compound

HRID 725768Notes

Reaction equation

HRID 725768 reaction equation
[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1C)=[C:11](OS(O)(=O)=O)[C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:24])([F:23])[F:22])(=[O:3])[CH3:2].[CH3:26][S:27][CH2:28][CH2:29][NH2:30]>>[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1[NH:30][CH2:29][CH2:28][S:27][CH3:26])=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:22])([F:23])[F:24])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 87697(2-(Methylthio)ethyl)amineHCID 86748764HCID 86748764, compound

Product 1

HCID 54076699HCID 54076699, compoundYield 76%

Procedure

3-Acetyl-6-chloro-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone (351 mg, 1 mmol) and methylthioethylamine (91 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (287 mg, yield: 76%).

Sources & evidence

ORD record
ord-f9129d94c8de4fec87c94f6e789d1b06
Source dataset
uspto-grants-1998_01
Patent number
US05707931

Reaction notes

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