Water → HCID 15451969, compound

Participants

Reaction Steps

4-Chloro-3-trifluoromethylphenol (10.0 g, 0.051 mol) and 4,6-dichloropyrimidine (3.7 g, 0.025 mol) were heated to 60° C. in dimethylsulphoxide (75 ml) with potassium carbonate (10 g) under nitrogen for 12 hours. The mixture was then poured into water and the product extracted into diethyl ether. The organic layer was dried using Na2 SO4, filtered and concentrated. The product, 4,6-bis(4-chloro-3-tri-fluoromethylphenoxy)pyrimidine, was obtained by column chromatography (eluting with 5:1, hexane:ethyl acetate) and recrystallization (diethyl ether/hexane). Yield 11.0 g (94%); melting point 111° C.

Provenance & Evidence