Phosphorus oxybromide → HCID 19709700, compound

Participants

Reaction Steps

4,6-Bis(3-trifluoromethylphenoxy)-pyrimidin-2-one (4.0 g, 0.0096 mol) and POBr3 (100g) were heated at 140° C. for 48 hours. The mixture was then poured onto a mixture of 2N NaOH (500 ml) and ice. The product was extracted into diethyl ether, dried using Na2SO4, filtered and concentrated under reduced pressure. The product was obtained by column chromatography (3:1, hexane: ethyl acetate) and recrystallization (ethyl acetate/hexane). Yield: 1.0 g (22%); melting point 126°-129° C.

Provenance & Evidence