Water → HCID 19709698, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-4,6-bis(4-fluoro-3-trifluoromethylphenoxy)pyrimidine (3.0 g, 6.7 mmol) was dissolved in carbon tetrachloride (75 ml) and the resulting solution was treated with t-butylnitrite (1.2 ml, 13.4 mmol). The mixture was heated at 30° C. for 48 hours and then poured into water. The product was extracted in dichloromethane, dried over sodium sulphate, filtered and concentrated under reduced pressure. The product, 4,6-bis(4-fluoro-3-trifluoromethyl-phenoxy)-2-chloro-pyrimidine, was obtained as an oil by column chromatography (eluting with 5:1, hexane:ethyl acetate). Yield 0.3 g (10%); mass 471 (M+ +H); N.m.r: 7.3-7.5 (6H, m, aromatics), 6.35 (1H,s,H-5).

Provenance & Evidence