Ammonia → HCID 19709716, compound

HRID 725825Notes

Reaction equation

HRID 725825 reaction equation
C([O:4][CH:5]([CH3:18])[CH2:6][CH2:7][C:8]1[CH:13]=[C:12](Cl)[N:11]2[N:15]=[CH:16][CH:17]=[C:10]2[N:9]=1)(=O)C.[NH3:19]>>[NH2:19][C:12]1[N:11]2[N:15]=[CH:16][CH:17]=[C:10]2[N:9]=[C:8]([CH2:7][CH2:6][CH:5]([OH:4])[CH3:18])[CH:13]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19608373HCID 19608373, compound

Product 1

HCID 19709716HCID 19709716, compound

Conditions

Temperature
105 °C

Procedure

The compound prepared in step (5) (4.3 g) and 25% aqueous ammonia (50 ml) were enclosed in a stainless steel sealed tube, heated at 105° C. for 14 hours and allowed to cool. The crystals precipitated were collected by filtration, washed with water and dried to provide 3.2 g of 7-amino-5-(3-hydroxybutyl)pyrazolo[1,5-a]pyrimidine as light yellow crystals.

Workup

  1. temperatureto cool
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-32e7768f154d492e9fbf990d7550b48a
Source dataset
uspto-grants-1998_01
Patent number
US05707997

Reaction notes

Loading…