Chlorotrimethylsilane → HCID 22372113, compound

Participants

Reaction Steps

Triethylamine (400 μl) and chlorotrimethylsilane (680 μl ) were added to 5 ml of a THF solution containing 500 mg of the crystals obtained in step (6), and the mixture was stirred at room temperature for 12 hours. After completion of the reaction, a saturated aqueous NaHCO3 solution was added and the reaction mixture was extracted with dichloromethane. The organic layer was collected, washed with water and a saturated saline solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. n-Hexane was added to the residue. The crystals precipitated were collected by filtration to provide 520 mg of 7-amino-5-(3-trimethylsilyloxybutyl) pyrazolo[1,5-a]pyrimidine as colorless crystals.

Provenance & Evidence