HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(4-Aminophenyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Propenoic acid, 3-(4-nitrophenyl)- | HCID 70156 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Aminophenyl)propionic acid | HCID 75451 | 99.6% |
Reaction Steps
A mixture of 155 g of 4-nitro-cinnamic acid in 1 l of methanol is mixed with 15 g of palladium on charcoal (10%) and 30 ml of water and hydrogenated at ambient temperature under 3 bar until no more hydrogen is taken up (2 hours). After filtration and evaporation of the solvent in a rotary evaporator, 2 lots of 300 ml of toluene are added in order to eliminate residual water and the solvent is distilled off in a rotary evaporator. In this way 132 g (quant.) of 3-(4-aminophenyl)propionic acid are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05707989 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-3854460a54784b7c98b1d7785b6ea196 |
| Source note | uspto-grants-1998_01 |