Sodium Hydroxide → HCID 178525468, compound

HRID 725848Notes

Reaction equation

HRID 725848 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([CH2:27][CH2:28][C:29]([O:31]C)=[O:30])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[Na+]>CO.O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:22][CH2:23][C@H:24]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])[CH2:25][CH2:26]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178500460HCID 178500460, compound

Product 1

HCID 178525468HCID 178525468, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Prepared from compound 240 of Example 1 by reaction with sodium hydroxide in a methanol/tetrahydrofuran mixture.

Sources & evidence

ORD record
ord-316efc63cf7b44bba2dcf0b2019aacec
Source dataset
uspto-grants-1998_01
Patent number
US05707989

Reaction notes

Loading…