Sodium Hydroxide → HCID 178525715, compound

HRID 725849Notes

Reaction equation

HRID 725849 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][C@H:22]4[CH2:27][CH2:26][C@H:25]([C:28]([O:30]C)=[O:29])[CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[Na+]>CO.O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][C@H:22]4[CH2:27][CH2:26][C@H:25]([C:28]([OH:30])=[O:29])[CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178501115HCID 178501115, compound

Product 1

HCID 178525715HCID 178525715, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Prepared from compound 244 of Example 1 by reaction with sodium hydroxide in a methanol/tetrahydrofuran mixture.

Sources & evidence

ORD record
ord-969dce1747524d2e98ab5d42a787911c
Source dataset
uspto-grants-1998_01
Patent number
US05707989

Reaction notes

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