HCID 86751904, compound → HCID 9808979, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 2A, but from 1.9 g of tert-butyl (2RS,4RS,5RS)-1-{2-[3-(3-(benzyloxycarbonyl)phenyl)ureido]acetyl}-5-phenyl-4-(phenylsulphonyl)pyrrolidine-2-carboxylate and 0.2 g of 10% palladium-on-charcoal in 75 cm3 of ethanol. After treatment, there are obtained 1.1 g of (2RS,4RS,5RS)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-4-phenylsulphonyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid [Rf =0.22; eluent: methylene chloride/methanol (80/20)].

Provenance & Evidence