Methanol → HCID 86751912, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 1.5 g of 2-tert-butyl 4-methyl (2RS,4RS,5SR)-1-{2-[3-(3-(methylthio)phenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate in a mixture of 2.8 cm3 of a normal aqueous potassium hydroxide solution, 15 cm3 of distilled water and 60 cm3 of methanol. After treatment, there are obtained 1.05 g of 2-tert-butyl hydrogen (2RS,4SR,5SR)-1-{2-[3-(3-(methylthio)phenyl)ureido]-acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate, melting at 130° C.

Provenance & Evidence