HCID 86751919, compound → HCID 19709468, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 2A, but from 3.6 g of benzyl (2RS,4SR,5RS)-3-{3-[2-(2-(3,3-dimethylpiperidino)carbonyl-5-(2-fluorophenyl)-4-phenylsulphonyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoate and 0.35 g of 10% palladium-on-charcoal in 200 cm3 of ethanol. After treatment, there are obtained 1.1 g of (2RS,4SR,5RS)-3-{3-[2-(2-(3,3-dimethylpiperidino)carbonyl-5-(2-fluorophenyl)-4-phenylsulphonyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid [Rf =0.21; eluent: methylene chloride/methanol (90/10)].

Provenance & Evidence