Methanol → HCID 19709630, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 2.62 g of tert-butyl (2RS,4RS,5SR)-4-acetyl-1-{2-[3-(3-(methoxycarbonyl)phenyl)ureido]acetyl}-5-phenylpyrrolidine-2-carboxylate in a mixture of 5 cm3 of a normal aqueous potassium hydroxide solution, 25 cm3 of distilled water and 100 cm3 of methanol. After treatment, there is obtained 0.6 g of (2RS,4SR,5SR)-3-{3-[2-(4-acetyl-2-tert-butoxycarbonyl-5-phenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 145° C.

Provenance & Evidence