HCID 86751932, compound → HCID 86751915, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 2A, but from 2.6 g of tert-butyl (2RS,4RS,5SR)-1-{2-[3-(3-(benzyloxycarbonyl)phenyl)ureido]acetyl}-5-phenyl-4-(phenylcarbamoyl)pyrrolidine-2-carboxylate and 0.3 g of 10% palladium-on-charcoal in 150 cm3 of ethanol. After treatment, there are obtained 2.05 g of (2RS,4RS,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-4-phenylcarbamoyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid [Rf =0.15; eluent: methylene chloride/methanol (80/20)].

Provenance & Evidence