Potassium Hydroxide → HCID 19709537, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 1.75 g of tert-butyl (2RS,4SR,5SR)-1-{2-[3-(3-(ethoxycarbonyl)phenyl)ureido]acetyl}-4-diethylaminocarbonyl-5-(2-fluorophenyl)pyrrolidine-2-carboxylate and 2.8 cm3 of a normal aqueous potassium hydroxide solution in a mixture of 15 cm3 of distilled water and 65 cm3 of methanol. After treatment, there is obtained 0.50 g of (2RS,4SR,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-4-diethylaminocarbonyl-5-(2-fluorophenyl)-1-pyrrolidinyl)-2-oxoethyl]ureido}-benzoic acid, melting at 150° C.

Provenance & Evidence