Potassium Hydroxide → HCID 19709591, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 3.5 g of (2RS,4SR,5RS)-5-(2-fluorophenyl)-1-{2-[3-(3-(methoxycarbonylmethyl)phenyl)ureido]acetyl}-2-morpholinocarbonyl-4-(phenylsulphonyl)pyrrolidine and 0.3 g of potassium hydroxide in a mixture of 30 cm3 of distilled water and 50 cm3 of methanol. After treatment, there are obtained 2.45 g of (2RS,4SR,5RS)-3-{3-[2-(5-(2-fluorophenyl)-2-morpholinocarbonyl-4-phenylsulphonyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid [Rf =0.64; eluent: methylene chloride/methanol (80/20)].

Provenance & Evidence