Potassium Hydroxide → HCID 19709466, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 3.75 g of (2RS,4SR,5RS)-5-(2-flurophenyl)-2-isobutylcarbamoyl-1-{2-[3-(3-(methoxycarbonylmethyl)phenyl)ureido]acetyl}-4-(phenylsulphonyl)pyrrolidine and 0.32 g of potassium hydroxide in a mixture of 55 cm3 of distilled water and 140 cm3 of methanol. After treatment, there are obtained 1.84 g of (2RS,4SR,5RS)-3-{3-[2-(5-(2-fluorophenyl)-2-isobutylcarbamoyl-4-phenylsulphonyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid [Rf =0.73; eluent: methylene chloride/methanol (80/20)].

Provenance & Evidence