Methanol → HCID 86751937, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 4.2 g of tert-butyl (2RS,4SR,5SR)-1-{2-[3-(3-(ethoxycarbonyl)phenyl)ureido]acetyl}-5-(2-fluorophenyl)-4-(isobutylcarbamoyl)pyrrolidine-2-carboxylate in a mixture of 6.8 cm3 of a normal aqueous potassium hydroxide solution, 30 cm3 of distilled water and 140 cm3 of methanol. After treatment, there is obtained 0.65 g of (2RS,4SR,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-5-(2-fluorophenyl)-4-isobutylcarbamoyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 160° C.

Provenance & Evidence