HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 725884Generated: November 2, 2026
tert-Butoxy bis(dimethylamino)methane → [2-(2-Chloro-6-methoxyquinolin-4-yl)ethenyl]dimethylamine
https://huagongshe.com/reaction/725884
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | 2-Chloro-6-methoxy-4-methylquinoline | HCID 224788 | — |
| Product | [2-(2-Chloro-6-methoxyquinolin-4-yl)ethenyl]dimethylamine | HCID 53676043 | 92.6% |
Reaction Steps
2-Chloro-6-methoxy-4-methylquinoline (25 g, 0.12 mol) and tert-butoxybis(dimethylamino)methane (Bredereck's reagent) (30 g, 0.17 mol) was stirred under heating at 120° C. for 1.5 hours. After cooling the reaction mixture, the precipitated crystals were washed with diisopropyl ether to obtain the title compound (29.2 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05708005 |
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| Source dataset | uspto-grants-1998_01 |
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| ORD ID | ord-028b9fadd9ed40c7aa6cd3c86c81a0b0 |
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| Source note | uspto-grants-1998_01 |
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