反应详情

A saturated ammonia/ethanol solution (40 ml) and Raney cobalt (4 g) were added to a solution of (2-chloro-6-methoxyquinolin-4-yl)acetonitrile (1.0 g, 4.3 mmol) in ethanol (150 ml), and the reaction mixture was stirred under an atmosphere of hydrogen (5 kgf/cm2) at room temperature for 3 hours. The Raney cobalt was filtered off, and then the solvent was evaporated under reduced pressure. The residue was washed with diethyl ether to obtain the title compound (855 mg, 84%).

1. filtrationThe Raney cobalt was filtered off
2. customthe solvent was evaporated under reduced pressure
3. washThe residue was washed with diethyl ether