Hydrogen Bromide → HCID 19709982, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-methyl-4-(7-methoxy-2-benzofuranyl)piperidine (5.6 g) and 48% HBr (40 mi) was stirred at 120° C. for 30 minutes. After cooling to room temperature, the mixture was neutralized with 10% sodium hydroxide solution and extracted with 1:1 ethyl acetate/1-butanol. The organic extract was washed with brine, concentrated and the resulting oil was chromatographed (silica gel, eluting with 20% MeOH/DCM and 0.5% NH4OH) to afford 1.9 g of 1-methyl-4-(7-hydroxy-2-benzofuranyl)piperidine.

Provenance & Evidence