Hydrogen Bromide → HCID 19709989, compound

Participants

Reaction Steps

A mixture of 1-methyl-4-(7-methoxy-2-benzofuranyl)-1,2,3,6-tetrahydropyridine (58.0 g), methanol (1.5 l), water (200 ml), 48% HBr (42.0 g), and platinum dioxide were shaken under hydrogen at room temperature for 6 hours. The mixture was filtered; the filtrate was concentrated in vacuo to the aqueous phase, neutralized with 5% Na2CO3 and extracted with CH2 Cl2. The organic phase was washed with water, dried (Na2 SO4) and concentrated in vacuo to give 59 g of the crude product, which was crystallized from methanol/water, m.p. 74°-75° C.

Provenance & Evidence