Sodium Carbonate → (6-Methylsulfonyl-indan-2-yl)-dipropyl-amine

Participants

Reaction Steps

To a solution of (6-methylsulfanyl-indan-2-yl)-dipropyl-amine (Example 12, 85 mg, 0.32 mmol) in trifluoromethanesulfonic acid (5 ml) was added 3-chloroperoxy-benzoic acid (90 mg, 75%, 0.39 mmol). The solution was then stirred for 2 h at room temperature. Another portion of 3-chloroperoxy-benzoic acid (20 mg 75%, 0.09 mmol) was added and the reaction mixture was stirred for an additional 1 h. The pH was adjusted to 11 with aqueous Na2CO3 and the layers were separated. The organic layer was dried and evaporated to dryness. The crude product was chromatographed (SiO2) using dichloromethane-methanol as eluant (19:1). Pooling of the pure fractions yielded 65 mg (69%) of (6-methylsulfonyl-indan-2-yl)-dipropyl-amine. The amine was converted to the hydrochloride and recrystallized from a mixture of 2-propanol and isopropyl ether. m.p. 190-192 (HCl); 1H NMR (300 MHz, CDCl3) δ 0.90 (t, 6H), 1.50 (m, 4H), 2.50 (t, 4H), 2.90-3.20 (m, 7H), 3.70-3.80 (m, 1H), 7.40 (d, J=8 Hz, 1H), 7.70-7.80 (d, 2H); 13C NMR (75.4 MHz, CDCl3) δ 11.97, 20.25, 36.43, 36.82, 44.68, 53.29, 63.08, 123.33, 125.18, 125.81, 138.65, 143.72, 148.89; MS m/e 295 (5, M+), 266 (100), 116 (18), 267 (18), 115 (15).

Provenance & Evidence