Hydrochloric Acid → HCID 86751883, compound

Participants

Reaction Steps

To a solution of (2S,4S)-4-acetylthio-N-(p-nitrobenzyloxycarbonyl)-2-[4-[N-(p-nitrobenzyloxycarbonyl)aminomethyl]phenoxymethyl]-pyrrolidine (786 mg, 1.23 mmol) in tetrahydrofuranmethanol (1:1, 20 ml), 1N aqueous sodium hydroxide (1.48 ml, 1.48 mmol) was added in a nitrogen stream under cooling with ice. The reaction solution was stirred at 2 hours, and 1N hydrochloric acid (1.6 ml, 1.6 mmol) was added thereto. The resulting mixed solution was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled off in vacuo to obtain a crude product of (2S,4S)-4-mercapto-N-(p-nitrobenzyloxycarbonyl)-2-[4-[N-(p-nitrobenzyloxycarbonyl)aminomethyl]phenoxymethyl]-pyrrolidine.

Provenance & Evidence