HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-Tribromobenzene → HCID 22881076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-Tribromobenzene | HCID 12279 | — |
| Reactant | tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate | HCID 10969557 | — |
| Product | HCID 22881076 | HCID 22881076 | 57% |
Reaction Steps
(2S,4R)-N-t-Butoxycarbonyl-4-t-butyldimethylsiloxy-2-(α-hydroxy-3,5-dibromobenzyl)pyrrolidine (19.6 g, yield: 56.9%) was prepared as a yellow oily substance, from (2S,4R)-N-t-butoxycarbonyl-4-(t-butyldimethylsiloxy)prolinal (20 g, 60.8 mmol), 1,3,5-tribromobenzene (19.13 g, 60.8 mmol) and 1.6M n-butyl lithium-hexane solution (49.4 ml, 79.04 mmol), in the same manner as in Reference Example 111-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05707987 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-83d05284e60340698f8624c8c0edc07e |
| Source note | uspto-grants-1998_01 |