1-Methyl-4-piperidone → HCID 22611274, compound

HRID 725970Notes

Reaction equation

HRID 725970 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:6][CH:5]=2.[CH3:16][N:17]1[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]1>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:20]1[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH:19]=1)=[CH:8][C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 22611412HCID 22611412, compound

Product 1

HCID 22611274HCID 22611274, compoundYield 33.4%

Procedure

Beginning with 1.37 gm (6.1 mMol) 2-methyl-5-methanesulfonylamino-1H-indole and 0.98 mL (7.9 mMol) 1-methyl-4-piperidone, 0.65 gm (33.3%) of the title compound were recovered as a yellow solid.

Sources & evidence

ORD record
ord-e1e42f5e9f9f46ccba5277c431ff8ed9
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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