Phenethyl isocyanate → HCID 22611234, compound

HRID 725995Notes

Reaction equation

HRID 725995 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][N:26]=[C:27]=[O:28])=[CH:20][CH:19]=1>>[CH2:25]([NH:26][C:27]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:28])[CH2:24][C:21]1[CH:22]=[CH:23][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 160602Phenethyl isocyanateHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611234HCID 22611234, compoundYield 65%

Procedure

Beginning with 15.0 mg (0.0655 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)-1H-indole and 12.51 mg (0.0852 mMol) 2-phenethyl isocyanate, 15.8 mg (65%) of the title compound were recovered.

Sources & evidence

ORD record
ord-fb68602772474216b8076dd92cb33682
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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