Isoxazole-5-carbonyl chloride → HCID 22611329, compound

HRID 726023Notes

Reaction equation

HRID 726023 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[O:18]1[C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=[N:19]1>>[O:18]1[C:22]([C:23]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:24])=[CH:21][CH:20]=[N:19]1

Participants

3

Reactant 2

HCID 2736707Isoxazole-5-carbonyl chlorideHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611329HCID 22611329, compoundYield 57.3%

Procedure

Beginning with 13 mg (0.056 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 8.21 mg (0.062 mMol) isoxazole-5-carbonyl chloride, 10.4 mg (57%) of the title compound were recovered.

Sources & evidence

ORD record
ord-e78051a1efa245cf86d6aa494a0e2231
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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