Cyclopropanecarboxylic acid → HCID 22611420, compound

HRID 726031Notes

Reaction equation

HRID 726031 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH:18]1([C:21](O)=[O:22])[CH2:20][CH2:19]1>>[CH:18]1([C:21]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:22])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611420HCID 22611420, compoundYield 77%

Procedure

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 9.0 μL (0.10 mMol) cyclopropanecarboxylic acid, 11.4 mg (77%) of the title compound were recovered.

Sources & evidence

ORD record
ord-27c93becf5054d1a8918f525dc83356f
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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