Nicotinic Acid → HCID 22611339, compound

HRID 726059Notes

Reaction equation

HRID 726059 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24](O)=[O:25])[CH:19]=1>>[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:25])[CH:19]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611339HCID 22611339, compoundYield 73.8%

Procedure

Beginning with 7.0 mg (0.03 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 11.1 mg (0.09 mMol pyridine-3-carboxylic acid, 7.4 mg of the title compound were recovered.

Sources & evidence

ORD record
ord-c7f5c4ddce3248e98a51a7a027c8f4d2
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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