1-Methyl-2-pyrrolecarboxylic acid → HCID 70107639, compound

HRID 726064Notes

Reaction equation

HRID 726064 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][N:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24](O)=[O:25]>>[CH3:18][N:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:25]

Participants

3

Reactant 2

HCID 814531-Methyl-2-pyrrolecarboxylic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 70107639HCID 70107639, compoundYield 107%

Procedure

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 19.0 mg (0.15 mMol) N-methylpyrrole-2-carboxylic acid, 18.0 mg (100%) of the title compound were recovered.

Sources & evidence

ORD record
ord-45fe7f43ee854c669229c6a3825b26ba
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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