2-Methyl-3-furoic acid → 5-(2-methyl-3-furoyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole

HRID 726065Notes

Reaction equation

HRID 726065 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][C:19]1[O:20][CH:21]=[CH:22][C:23]=1[C:24](O)=[O:25]>>[CH3:18][C:19]1[O:20][CH:21]=[CH:22][C:23]=1[C:24]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:25]

Participants

3

Reactant 2

HCID 2447562-Methyl-3-furoic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 226112565-(2-methyl-3-furoyl)amino-3-(1-methylpiperidin-4-yl)-1H-indoleYield 4%

Procedure

Beginning with 7.0 mg (0.03 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 11.3 mg (0.09 mMol) 2-methyl-3-furoic acid, 0.4 mg (4%) of the title compound were recovered.

Sources & evidence

ORD record
ord-ad71a8d7c87d48c7bb8aaa346f85a425
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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