4-methoxythiophene-3-carboxylic acid → HCID 22611498, compound

HRID 726073Notes

Reaction equation

HRID 726073 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][O:19][C:20]1[C:21]([C:25](O)=[O:26])=[CH:22][S:23][CH:24]=1>>[CH3:18][O:19][C:20]1[C:21]([C:25]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:26])=[CH:22][S:23][CH:24]=1

Participants

3

Reactant 2

HCID 27783794-methoxythiophene-3-carboxylic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611498HCID 22611498, compoundYield 109.2%

Procedure

Beginning with 7.0 mg (0.03 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 14.2 mg (0.09 mMol 4-methoxy-3-thienoic acid, 12.1 mg of the title compound were recovered.

Sources & evidence

ORD record
ord-9e1f6047eb1042799219c3cfd29949c7
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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