Water → 2-Bromo-N-isopropyl-N-methyl-acetamide

HRID 726103Notes

Reaction equation

HRID 726103 reaction equation
[C:1]([Br:4])(=O)[CH3:2].[CH3:5][NH:6][CH:7]([CH3:9])[CH3:8].[OH2:10]>CCOCC>[Br:4][CH2:1][C:2]([N:6]([CH3:5])[CH:7]([CH3:9])[CH3:8])=[O:10]

Participants

5

Reactant 3

HCID 962WaterHCID 10482Acetyl bromideHCID 78485N-Methylisopropylamine

Product 1

HCID 205943482-Bromo-N-isopropyl-N-methyl-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 10 cm3 of acetyl bromide in 150 cm3 of ether, cooled to -20° C., one adds a solution of 26 cm3 of methylisopropylamine in 100 cm3 of ether. One leaves the mixture to return to 20° C. and agitates it for 30 minutes at 20° C. One dilutes with water, decants, extracts with ether, dries and separates by distillation. One obtains 13 g of expected product. B.p.=71°/72° under 1 mmHg.

Workup

  1. customOne leaves the mixture
  2. customto return to 20° C.
  3. customfor 30 minutes
  4. customat 20° C
  5. customdecants
  6. distillationextracts with ether, dries and separates by distillation

Sources & evidence

ORD record
ord-e5193ee1ae704fd8b5665b8cd0e95805
Source dataset
uspto-grants-1998_01
Patent number
US05707982

Reaction notes

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