Acetic Anhydride → HCID 22845950, compound

HRID 726104Notes

Reaction equation

[O:1]=[C:2]1[CH2:19][CH2:18][C:17]2[C:4]([CH2:5][CH2:6][C@@H:7]3[C:16]=2[C@@H:15]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([N:32]([CH2:34][C:35]([F:44])([F:43])[C:36]([F:42])([F:41])[C:37]([F:40])([F:39])[F:38])[CH3:33])=[O:31])[CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C:11]2=[O:45])=[CH:3]1.[C:46](OC(=O)C)(=[O:48])[CH3:47].C(Br)(=O)C>>[C:46]([O:1][C:2]1[CH:19]=[CH:18][C:17]2[C@@H:16]3[C@H:7]([C@H:8]4[C@@:12]([CH2:14][C@@H:15]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([N:32]([CH2:34][C:35]([F:43])([F:44])[C:36]([F:41])([F:42])[C:37]([F:38])([F:39])[F:40])[CH3:33])=[O:31])([CH3:13])[C:11](=[O:45])[CH2:10][CH2:9]4)[CH2:6][CH2:5][C:4]=2[CH:3]=1)(=[O:48])[CH3:47]

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 10482Acetyl bromide

HCID 22845949HCID 22845949, compound

Product 1

HCID 22845950HCID 22845950, compound

Procedure

One operates as in Stage B of Example 3 starting with 345 mg of the product obtained in Stage A above using 0.4 cm3 of acetic anhydride and 0.2 cm3 of acetyl bromide. One obtains 323 mg of expected product.

Sources & evidence

ORD record: ord-6faed9bb99ff46fda5c8bfce5f60815c
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05707982

Reaction notes

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