HCID 67615161, compound → HCID 53807267, compound

Participants

Reaction Steps

A solution of 17β-Hydroxymethyl-3b-hydroxy-6-t-butoxycarbonyl-6-azaandrost-4-ene (prepared as described in Example 5 above), in chloroform (250 mL) is treated with activated manganese(IV) oxide. After stirring 3.5 h, the manganese salts are removed by filtration through Celite. The solution is concentrated and chromatographed on silica gel (50% ethyl acetate/hexanes) to give 17β-hydroxymethyl-6-t-butoxycarbonyl-6-azaandrost-4-en-3-one of sufficient purity to carry on to subsequent steps; yield 9.75 g (98%).

Provenance & Evidence