HCID 18694899, compound → HCID 15871216, compound

Participants

Reaction Steps

A solution of 2-t-butyl-5-trifluoromethylnitrobenzene (26.0 g, 105 mmol) in ethanol (95%, 100 mL) is treated with 10% Pd/C (2 g) and placed under a hydrogen atmosphere (40 psi) on a Parr apparatus for 1.5 h. The mixture is filtered, concentrated and purified by silica gel chromatography (7:1 hexane to ethyl acetate) to give 2-t-butyl-5-trifluoromethylaniline as an oil; yield: 20.2 g (89%).

Provenance & Evidence