HCID 19710668, compound → HCID 9802887, compound

Participants

Reaction Steps

The procedure as described for Example 17 is followed. Starting from 120 mg of (-)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyanophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (atropisomer ratio in the elution sequence from chiral HPLC 98: 2; [α]20 D =7.2 (c=0.9, MeOH)), after electrolysis at 10-40 mA, 80 mg (67% of theory) of isopropyl 2-methoxyethyl 4-(2-chloro-3-cyanophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate are obtained in the enantiomer ratio 61.3:38.7.

Provenance & Evidence